According to Cleary, the KRAS gene, which causes about half of all human cancers, is mutated in more than 90% of cases of pancreatic cancer. However, a medication to turn off this specific gene has not yet been developed. One of oncology's "holy grails" is figuring out how to successfully target KRAS with a drug, according to Cleary. A Nobel Prize could be given to whoever develops an efficient KRAS targeted therapy because it is so crucial to oncology.

The bamboo species Dendrocalamus sinicus is the world's largest, reaching 40 m in height and 30 cm in diameter.

The Chinese government started mass-producing it in the 14th century. Manufacturers weren't able to guarantee Splinter-Free Toilet Paper until 1935.

Brazil produces roughly 40% of the world's coffee, far outpacing other coffee-producing countries. They've managed to keep the top spot for the last 150 years, and their coffee plantations cover approximately 27,000 km2. I don't think any other country will be able to dethrone them any time soon!

Akira, a highly praised film, was also a significant technological success for the Japanese animation industry. It had 2,212 shots and 160,000 single images. This is around 2-3 times the cost of the average anime film. The majority of the film's scenes were planned to take place at night, which was normally avoided by animators during those days due to such sequences needing exceptionally high colour utilisation and that too with tremendous precision to make the picture seem pleasant. Akira defied all expectations by employing an incredible 327 hues throughout the picture, 50 of which were produced specifically for the film and its scene needs.

We say "cheese" because it makes us happy, but if Victorian-era people saw our delighted grins, they'd laugh. Smiling in pictures was once considered demeaning and reserved for the impoverished and inebriated. To maintain a more serious appearance in their photographs, they would utter "prunes," a word so uninteresting that the odds of it eliciting a grin were minimal to none.

Who can forget Gwyneth Paltrow's sobbing during her 1999 acceptance speech for Best Actress for "Shakespeare in Love"? Or Julia Roberts, who burst out laughing and neglected to thank "Erin Brockovich," the subject of her movie. However, Greer Garson, an actress, received the award for Best Supporting Actress in 1934 and delivered a speech that was seven minutes long.

There’s a special version of braille just for mathematics called the Nemeth Code. It was invented by Dr. Abraham Nemeth and can be used to transcribe math, algebra, and calculus.

Stingrays may appear to be soaring through the water, but a closer look reveals that they are actually moving through with a smooth flapping motion. The majority of species move by undulating their bodies, much like an aquatic wave, however, some prefer to flap their sides like wings. Stingrays in South Africa travelled at a speed of 1.35 kilometres per hour (0.83 miles per hour), and some species made migrations of up to 850 kilometres, according to research by the Save Our Seas Foundation (528 miles).

It takes one particularly terrifying creep to inspire Hannibal Lecter, Norman Bates, and Leatherface, but that's the legacy left by horrifying serial killer Ed Gein. When he was finally caught and his house of horrors in Plainfield, Wisconsin, discovered, police found masks and lampshades made from human skin, among plenty of other atrocities. His astonishing depravity proved a source of creative inspiration.

Ladakh is home to a specialist in the creation of fake glaciers. Chewang Norphel, a retired civil engineer, saw a little brook had frozen beneath the trees. Soon after, he became involved in waster shed development and built more than 15 artificial glaciers. His longest glacier was over 1000 feet long and could support a whole settlement of 900 people.

Your spine protects and safeguards the spinal cord. As you may be aware, the base of the brain is linked to the spinal cord. They are collectively known as the central nervous system (CNS). Can you believe one of your body's most vital components weighs only 35 grams?

Alabama residents who dress in clergy attire are thought to be breaching the law and might face a $500 fine and up to a year in jail. Reminder to self: don't dress up as a priest, rabbi, or nun on October 31 in Alabama.

Barbie's ridiculously svelte-yet-busty figure has been at the center of many-body image controversies over the years. Barbie is made by Mattel on a 1/6 scale, which is the standard scale for action figures. Barbie's measurements would then be 38-18-28. (reports vary based on versions of dolls). Various outlets and organizations have pointed out that her proportions are more than just an unrealistic standard; they would render a human woman physically incapable of walking, holding her head up, or having fully functioning internal organs. Mattel responded to calls for change by releasing a variety of dolls with different body types, skin tones, and hairstyles.

Pulpally in Wayanad is home to Kerala's only Luv Kush Temple. The 'Sita Lava Kusha Temple is said to have formerly been inhabited by Sita Devi.

The Denmark Strait cataract is the world's highest underwater waterfall, with a drop of 11,500 feet (3,505 metres) in the Atlantic Ocean.

On August 15, 1947, India gained independence from British rule, but the Portuguese refused to relinquish control of Goa. Goa's independence struggle was fought both within and outside the state, and on December 17, 1961, the Indian Army, air force, and naval forces invaded Goa and overpowered the under-prepared Portuguese army. The Portuguese governor officially surrendered on December 18th, and Goa became a part of India the next day! Every year on December 19th, Goa commemorates its second independence day.

Making seven wishes while jumping seven waves is considered good luck, so you can bet on a good old New Year's beach celebration in Rio de Janeiro!

Your liver uses cholesterol to make bile acids, and bile is the only way your body can get rid of excess cholesterol.

Your body also uses cholesterol to make sex hormones, like estrogen and testosterone. If you have liver disease, you’ll have trouble absorbing fats as well as hormonal problems.

But fats are chemically different from cholesterol; the body burns fats for energy. That’s why food labels list fat and cholesterol separately.

It is known that these insects live in a variety of locations throughout the world. Most of South America, including Costa Rica and Peru, as well as New Zealand, Australia, and much of the continent of Mymaridae are where they can be found most frequently.

Arsenal on the Kyiv city metro line (Sviatoshynsko - Brovarska Line) is currently the world's deepest metro stop. It is 105.5 meters deep. Escalators transport you deep underground so that you can catch the train. Arsenal had to be 105.5 m deep because it had to bypass the Dnieper River, which rises above and surrounds Kyiv. You will ride the escalator for five minutes to reach 105.5 m deep down the station.

On November 17, 1873, the three neighboring cities of Pest, Buda, and Buda merged to form Budapest. The unification was a significant historical event that resulted in the city's rapid development. Finding a name for the new capital, on the other hand, sparked a lot of debate. Hunvár, Etelvár, and Honder were among the names proposed. Budapest eventually won, becoming the official name of Hungary's capital.

A fog bow, as the name implies, is a rainbow that appears in fog rather than during rainfall. They are slightly fainter and more difficult to see than rainbows, but you are more likely to see the entire circle of the optical effect. Because fog is made up of smaller water droplets than raindrops, the full spectrum of colours in a fog bow is difficult to distinguish and appears as a bow of faint red and blue.

For the longest time, it was assumed that witchcraft was primarily a female activity. However, there are male counterparts to witches, who are commonly referred to as wizards, warlocks, or sorcerers. Throughout history, countless men and women have been persecuted on suspicion of practicing witchcraft.